About Transcranial Magnetic Stimulation
Transcranial Magnetic Stimulation is proven as one of the safest and most effective alternative treatments for all types of depression.
Treating depression with TMS offers patients a unique opportunity to deal with depression symptoms without medication or side effects. NeuroStar TMS Therapy system is the first and only non-systemic and non-invasive transcranial magnetic stimulation device cleared by the U.S. Food and Drug Administration (FDA) for the treatment of patients with major depression who have not benefited from prior antidepressant treatment. NeuroStar TMS Therapy uses highly a focused, pulsed magnetic field to stimulate function in targeted brain regions offering these important benefits:
- Non-invasive – This alternative depression treatment doesn’t require surgery, anesthesia or sedation. You’ll remain awake during your session. Shortly after your session, you’ll resume your normal activities. >> LEARN WHAT TO EXPECT FROM TMS THERAPY
- Non-systemic – TMS depression therapy is not a medication; it is not taken orally so it does not circulate throughout your bloodstream. >> LEARN HOW TMS THERAPY WORKS
Background: Transcranial Magnetic Stimulation
Since the 1980s, transcranial magnetic stimulation has been used to study nerve fibers that carry information about movements from the brain to the spinal cord and onto the muscles. In the late 1990s physicians began to explore the potential therapeutic benefits of transcranial magnetic stimulation for the treatment of a variety of diseases, with depression being the most thoroughly studied to date. Since then, more than 30 randomized, controlled trials studying transcranial magnetic stimulation as a treatment for depression have been published by investigators throughout the world.
NeuroStar TMS (transcranial magnetic stimulation) Therapy was recently FDA-cleared for patients suffering from depression who have not achieved satisfactory improvement from prior antidepressant medications.* Using pulsed magnetic fields, transcranial magnetic stimulation therapy stimulates the part of the brain thought to be involved with mood regulation. TMS Therapy is a short outpatient procedure, performed in your psychiatrist’s office under their supervision while you remain awake and alert. Your initial course of treatment is about 37 minutes daily over 4-6 weeks. >> LEARN WHAT TO EXPECT FROM TMS
Clinical trials prove effectiveness of NeuroStar TMS Therapy
NeuroStar TMS Therapy® has gone through clinical trials that have proven that it is effective in treating adult patients suffering from major depressive disorder, all of whom had not reported satisfactory improvement with previous antidepressant medication. It has not, however, been studied in patients who have not received prior antidepressant treatment. Its effectiveness has also not been established in patients who have failed to receive benefit from two or more prior antidepressant medications at minimal effective dose and duration in the current episode.
Perhaps the most promising results were from a study where all patients received active treatment, approximately 50% of the patients treated with NeuroStar TMS Therapy experienced significant improvement in their depression symptoms. About a third of the patients treated with NeuroStar TMS Therapy experienced complete symptom relief at the end of six weeks.
- In a controlled clinical trials comparing the NeuroStar TMS Therapy® system to an inactive device, patients treated with active NeuroStar TMS Therapy experienced a 22.1% average reduction of their depression symptoms, compared to a 9% average reduction of depression symptoms in patients receiving inactive treatment.
- Patients treated with NeuroStar® also experienced significant improvement in anxiety and physical symptoms (such as appetite changes, aches and pains, and lack of energy) associated with depression.
Proven safe with few side effects
Over 10,000 active treatments were performed across all NeuroStar® clinical trials demonstrating its safety, and also proving that transcranial magnetic stimulation caused few side effects and is generally well tolerated by patients. The most common side effects reported during clinical trials were headache and scalp pain or discomfort — generally mild to moderate and occurring less frequently after the first week of treatment. Fewer than 5% of patients discontinued treatment with NeuroStar TMS Therapy due to adverse events.
- No seizures – estimated risk of seizure under ordinary clinical use is approximately 1 in 30,000 treatments (0.003% of treatments) or 1 in 1000 patients (0.1% of patients).
- No systemic side effects – weight gain, sexual dysfunction, sedation, nausea, dry mouth,
- No adverse effects on concentration or memory
- No device-drug interactions
Note: Patients should be carefully monitored for worsening symptoms, signs or symptoms of suicidal behavior and/or unusual behavior. Families and caregivers should also be aware of the need to observe patients and notify their treatment provider if symptoms worsen. NeuroStar TMS Therapy should not be used (is contraindicated) in patients with implanted metallic devices or non-removable metallic objects in or around the head. NeuroStar TMS Therapy should be used with caution in patients with implants controlled by physiological signals. This includes pacemakers and implantable cardioverter defibrillators (ICDs).